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. 2011 Feb 10;6(2):e16586. doi: 10.1371/journal.pone.0016586

Figure 6. Model depicting the regulation of TXA2 generation by G12/13 pathways and integrins through FAK.

Figure 6

Integrin clustering leads to FAK activation (1). Fibrinogen receptor antagonist SC57101 prevents integrin clustering hence inhibits FAK activation (2). FAK can be activated in an integrin-independent manner by G12/13 pathways (3). FAK is activated downstream of Rho kinase and SFKs upon stimulation of G12/13 pathways (4). FAK can be inhibited by TAE-226 (5). Common effector molecule downstream of integrins and G12/13 pathways contributing to thromboxane generation are unknown (6).