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. 2011 Feb 10;6(2):e16867. doi: 10.1371/journal.pone.0016867

Figure 4. Phylogenetic tree of the PRAME gene family.

Figure 4

Two major PRAME/PRAMEY clades are shown in this tree. The PRAME locus on HSA22 and its syntenic orthologs in other species are clustered with the bovine PRAME and PRAMEY loci in Clade I (branches in red). The orthologs on the X-chrs of horse and mouse are also clustered with Clade I. The PRAME orthologs syntenic to HSA1 are clustered in Clade II (branches in light blue), which contains three sub-clusters, IIa (Artiodactyla), IIb (Primates) and IIc (Rodentia). The tree was built based on the ML method and bootstrap values (1000 replicates) are shown above the branches. The branches corresponding to partitions reproduced in less than 80% bootstrap replicates are collapsed.