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. 2011 Feb 10;6(2):e16867. doi: 10.1371/journal.pone.0016867

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Chang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. The dN/dS ratio distributions in different clades. Clade I has the lowest mean and median dN/dS ratios. The vertical axis represents the dN/dS ratio. The asterisk (*) represents the outliers of the data. B. Map of the positively selected sites detected in Clade IIa to the PRAME protein model. The selected sites derived from PAML analyses are mapped to the protein homology model. Eight of the 12 selected sites (red) are clustered in the inner concave region of the protein model. The model was built based on the PRAME gene (GenBank acc. no. XM_001256020.1) on BTA16. The predicted DNA binding site is highlighted in orange. The LXXLL motifs are highlighted in pink.