Table II.

Concentrations and Ranks of Urinary Estrogens.

	Cases (N=76)			Healthy Controls (N=74)				Biopsy Controls (N=35)				PH/B
	Median	25th, 75th P	Rank	Median	25th, 75th P	Rank	PH	Median	25th, 75th P	Rank	PB
EM
E1	1.17	0.82, 1.78	2	1.06	0.73, 1.84	3	0.88	1.36	0.83, 2.52	2	0.20	0.15
E2	0.68	0.41, 1.36	5	0.58	0.39, 0.99	6	0.22	0.59	0.41, 1.08	5	0.68	0.57
Catechol Estrogens
2-OHE1	0.77	0.43, 1.47	4	1.04	0.60, 1.82	4	0.13	0.82	0.29, 1.55	4	0.72	0.12
2-OHE2	0.20	0.11, 0.39	11	0.24	0.13, 0.39	10	0.31	0.18	0.11, 0.34	10	0.76	0.23
4-OHE1	0.26	0.13, 1.23	9	0.23	0.16, 0.45	11	0.56	0.17	0.11, 0.41	11	0.15	0.23
16α pathway
16α-OHE1	0.47	0.22, 1.15	6	0.63	0.30, 1.03	5	0.30	0.57	0.22, 1.11	6	0.82	0.68
17-epiE3	0.11	0.07, 0.21	12	0.16	0.10, 0.29	12	0.05	0.10	0.08, 1.16	12	0.44	0.01
E3	2.17	1.32, 4.91	1	2.50	1.51, 2.50	1	0.29	2.87	1.36, 17.89	1	0.18	0.56
16-KE2	1.00	0.61, 1.61	3	1.16	0.84, 2.19	2	0.03	0.98	0.46, 2.17	3	0.97	0.12
16-epiE3	0.35	0.24, 0.55	7	0.41	0.27, 0.60	7	0.20	0.32	0.21, 0.49	7	0.58	0.10
Methoxy Estrogens
2-MeOE1	0.26	0.18, 0.49	8	0.35	0.23, 0.58	8	0.22	0.27	0.18, 0.42	8	0.73	0.12
2-MeOE2	0.07	0.05, 0.13	14	0.08	0.04, 0.19	14	0.56	0.07	0.05, 0.16	14	0.95	0.61
3-MeOE1	0.20	0.11, 0.40	10	0.24	0.11, 0.56	9	0.58	0.24	0.13, 0.57	9	0.31	0.64
4-MeOE1	0.08	0.05, 0.15	13	0.09	0.04, 0.18	13	0.44	0.09	0.05, 1.13	13	0.96	0.47
4-MeOE2	0.06	0.04, 0.11	15	0.08	0.04, 0.13	15	0.45	0.07	0.04, 0.12	15	0.44	0.84
Total	10.75	6.59, 19.58		11.65	7.52, 18.58		0.41	15.23	9.11, 28.94		0.10	0.16
2-OHE1/16α-OHE1	1.71	0.55, 3.45		1.46	0.55, 3.07		0.87	1.39	0.45, 3.47		0.73	0.78
Creatinine (mg/dL)	102.5	62.0, 158.2		104.1	63.0, 138.6		0.89	98.6	59.6, 152.1		0.94	0.81
Total protein (mg/dL)	7.0	5.0, 13.0		7.0	5.0, 11.0		0.54	8.5	5.0, 22.0		0.11	0.04

Estrogen metabolite values are denoted as pg estrogen metabolite normalized by creatinine (mg/dL). Rank is based on estrogen metabolite concentration

There was insufficient urine volume for 5 participants (1 case, 3 healthy controls, 2 biopsy controls) to assay for creatinine, therefore estrogen metabolite measurements are not presented for these subjects.

E1 concentration was below the detection limit for 1 healthy control, 2-OHE1 for 2 cases and 4 healthy controls, 2-OHE2 for 1 case and 1 biopsy control, 4-OHE1 for 2 cases and 2 healthy controls, 2-MeOHE1 for 1 case and 1 biopsy control, 4-MeOE2 for 3 cases, 1 healthy and 2 biopsy controls

%= median percentage of individual estrogen compared to total estrogen

25^th, 75^th P = 25^th, 75^th Percentiles

P_H: comparison between cases and healthy controls

P_B: comparison between cases and biopsy controls

P_H/B: comparison between healthy and biopsy controls

Significantly different comparisons based on Wicoxon Rank Sum test are bolded.