Table 2.
Microsatellite Markers Used in Diagnosis of Microsatellite Instability in Colorectal Cancer
| Marker | Gene | MS repeat | Chromosomal location | Location of MS repeat |
|---|---|---|---|---|
| D2S123 | Linked to MSH2 | CA (n) | 2p16 | |
| D5S346 | Linked to APC | CA (n) | 5q22-23 | |
| D17S250 | Linked to p53 | CA (n) | 17q12 | |
| BAT-25 | c-kit | A (25) | 4q12 | Intron 16 |
| BAT-26 | MSH2 | A (26) | 2p21 | Intron 5 |
| Pentaplex panel of mononucleotide repeat markers | ||||
| BAT-25 | c-kit | A (25) | 4q12 | Intron 16 |
| BAT-26 | MSH2 | A (26) | 2p21 | Intron 5 |
| NR-21 | SLC7A8 | T (21) | 14q11 | 5′ UTR |
| NR-24 | Zinc finger 2 (ZNF-2) | T (24) | 2q11 | 3′ UTR |
| NR-27 | Inhibitor of apoptosis protein-1 | A (27) | 11q22 | 5′ UTR |
| Other relevant microsatellite markers | ||||
| CAT25 | Caspase-2 (CASP2) | T (25) | 7q34 | 3′ UTR |
MS, microsatellite; NCI, National Cancer Institute.