Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Oct 8;86(8):848–866. doi: 10.2183/pjab.86.848

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Signal transduction pathways of the four PGE receptor subtypes. EP1 is coupled to G_q/11 (G_q) and intracellular Ca²⁺ mobilization. EP2 and EP4 are coupled to the G_s/adenylyl cyclase/cAMP/protein kinase A (PKA) pathway. Recently, it was shown that the two receptors are also coupled to the β-arrestin (βArr)/Phosphoinositide 3-kinase (PI3-K) pathway. The EP3 receptor is mainly coupled to G_i, but in particular cell types, EP3 augments EP2/EP4-induced cAMP formation via the G_q/phospholipase C/Ca²⁺ pathway.