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. 2010 Oct 8;86(8):848–866. doi: 10.2183/pjab.86.848

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© 2010 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Regulation of PGE receptor gene expressions. A. Constitutive expression of PGE receptor genes in different cell types of kidney. Schematic representation of the distribution of PGE receptors in the nephron (center panel). EP1 is expressed in the collecting duct (blue), EP3 is expressed in thick ascending limb (yellow), and EP4 is expressed in the glomerulus (red). EP1 and EP3 are involved in inhibition of water and ion transport, respectively. EP4 is involved in regulation of glomerular filtration rate. B. Inducible gene expression of COX-2 and the EP2 receptor in cumulus cells (hormonal stimuli) or macrophage (proinflammatory stimuli). In these cells, gene expression of COX-2 and EP2 is induced in a similar manner. As a result, COX-2-derived PGE₂ acts on the EP2 receptor, and elicits functional changes via the G_s/cAMP/PKA pathway in an autocrine fashion.