Figure 2.

Comparison of the simulated and experimental spreading behaviors based on the dynamic profile of actin modulators. The output from the signaling model from the control case is used as input for the spreading model. (A) Spreading behavior averaged over 24 simulations. (i) Total number of filaments. (ii) Radius map. (iii) Velocity map. (B) Comparison with experimental data using the (i) fold change in radius and (ii) circularity. The experiments were conducted with fibroblasts spreading on fibronectin-coated surfaces (see Materials and Methods).