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. 2011 Feb 16;100(4):845–857. doi: 10.1016/j.bpj.2010.12.3732

Figure 3.

Figure 3

Simulations of spreading behavior in the absence of Cdc42 and WASP; comparison with experiment. Simulations using concentration profiles for Arp2/3, gelsolin, and G-ATP-actin in the case in which Cdc42 and WASP initial concentrations were set to zero are compared with spreading experiments performed with Cdc42DN fibroblasts and wiskostatin inhibition of WASP. Panels A and B show the fold change in radius in these cases compared with control; there is a small reduction in the spreading radius. Panels C and D compare the circularity profiles in these cases. Simulations predict no change in cell shape during spreading in the absence of Cdc42 or WASP, and experiments (D) agree with this prediction.