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. 2011 Feb 8;19(2):155–161. doi: 10.1016/j.str.2010.12.007

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Copyright © 2011 Elsevier Ltd. All rights reserved.

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Scheme of Cross-Crystal Averaging to Determine the Structure of SARS Coronavirus Receptor-Binding Domain Complexed with Human ACE2

The masks covering the two lobes of the ACE2 in the reference molecule (scRBD-ACE2 complex) are shown in red and blue, respectively. The matrices that move the reference molecule to the NCS-related molecule and the molecules in the second crystal are indicated by arrows. An additional mask is generated to generously cover the missing scRBD domain in the reference molecule. The boundary of this mask is also drawn in dashed lines in the NCS related molecule.