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Alternative and complementary pathways for glutathione reductase and deglutathionylase activities in E. granulosus. A, at low GSSG concentrations, proteinS-SG mixed disulfides (PrS-SG) and GSSG are efficiently reduced by TGR, via its “in-built” Grx domain that receives electrons from the TR domains. B, at high GSSG concentrations, the Grx domain is inhibited, and cytosolic and mitochondrial Trxs provide a rescue pathway for GSSG and PrS-SG mixed disulfides reduction.
