TABLE 1.
Functional categories
Shown are the functional categories enriched in gene clusters a–d of Fig. 4C. Functional enrichment was determined using FunSpec (35). The complete list of genes in each cluster and their functional groupings can be found in the supplemental material.
| Cluster | Category | p valuea | Genes | Classification source |
|---|---|---|---|---|
| a | Sphingolipid biosynthetic process | 5.65 × 10−4 | SUR2 SUR1 | GO Biological Process |
| Cell wall | 5.87 × 10−5 | CWP1 GFA1 EXG1 | GO Cellular Component | |
| b | Regulation of cyclin-dependent protein kinase activity | 1.10 × 10−5 | CLN1 PCL1 CLN2 | GO Biological Process |
| Cell cycle | 9.69 × 10−5 | MCD1 YOX1 CLN1 PCL1 | GO Biological Process | |
| Cell division | 3.07 × 10−4 | MCD1 CLN1 PCL1 CLN2 | GO Biological Process | |
| c | Reproduction | 5.23 × 10−4 | PCL2 GIC2 RAX2 | GO Biological Process |
| Regulation of cell shape | 1.52 × 10−3 | GIC2 GIC1 | GO Biological Process | |
| d | Telomere maintenance via recombination | 1.95 × 10−3 | YRF1−1 RFA2 | GO Biological Process |
| DNA replication | 9.56 × 10−3 | PLM2 CDC45 RFA2 | GO Biological Process |
a The p value is the probability of chance enrichment, and only genes with p < 0.005 (except for cluster d in which the cut-off is p < 0.01) are shown.