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Effect of dietary protein restriction on hepatic one-carbon metabolism in the rat. Shown are the substrate fluxes that were increased (thick arrows) as well as the differentially regulated enzymes. Red up and blue down. SAM, AdoMet; CβL, cystathionine β-synthase; CγS, cystathionine γ-lyase; THF, tetrahydrofolate; CSAD, cysteinesulfinic acid decarboxylase; GCL, glutamate-cysteine ligase.
