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. 2010 Dec 13;286(7):5667–5679. doi: 10.1074/jbc.M110.153866

FIGURE 5.

FIGURE 5.

The involvement of MTP in chemoattractant-induced mobility of Sox-GFP+ NP cells. A, control or MTP siRNA-transfected NP cells (MTP KD) were plated on the top chamber of the transwell. To the bottom chamber, the conditioned medium of BV2 cells equivalent to 0.75 × 106 (1X), 1.5 × 106 (2X), or 2.25 × 106 (3X) cells were added. Data were normalized to control or MTP siRNA-transfected NP cells cultured in the regular neural growth medium (set at 1 shown with dark dotted line). B, non-silencing control siRNA-transfected NP cells (dark dot-filled bars) or MTP siRNA-transfected NP cells (waving line-filled bars) were plated in the top chamber of the transwell. HGF (20 ng/ml), SDF-1α (50 ng/ml), and VEGF (100 ng/ml) were added to the bottom chamber of the culture. Data were normalized to the no-chemokine control culture (set at 1 shown in dark dotted line). Data were from three independent experiments. *, p ≤ 0.05; **, p ≤ 0.01.