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ANF binds in a narrow activity site cavity of P450 1B1 that is similar to that of P450 1A2. Helix I forms one wall of the slot. Helix F distorts as it crosses the slot and places a conserved Phe (Phe231 and Phe226) so that the aromatic side chain stacks against ANF. A second conserved Phe (Phe134 and Phe125) on the BC loop also borders the slot. ANF and heme are rendered with yellow and pink carbons, respectively. Note the different orientations of ANF in the two active site cavities.
