Solvent-accessible surfaces of the substrate binding cavities of P450s 1B1 and 1A2 are rendered as mesh surfaces. Side views are shown for each enzyme (top), and a superposition of the two is shown as an edge view and an opposing side view (helix I removed) (bottom). Carbons are colored cyan, gray, and pink for 1B1, 1A2, and the heme, respectively.