TABLE 1.
Sequence of OVA peptide variants and the morphology of aggregates obtained by incubation at 80 °C
| Region | Sequence | Solubility and amyloid fibril formation |
|---|---|---|
| Amyloidogenic core regions | ||
| hB | 32IAIMSALAMVYL43 | Highly insolublea |
| 32IAIMSA37 | Soluble,b NDc | |
| 38LAMVYL43 | Amyloid | |
| s3A | 172MVLVNAIVFK181 | Amyloid |
| 172MVLV175 | Soluble, ND | |
| 178IVFK181 | Soluble, ND | |
| s4B | 364FLFCIK369 | Amyloid |
| s5B | 376VLFFGR381 | ND |
| Reactive center loop | 338GREVVGSAEAGVDA351 | Soluble, ND |
| 346EAGVDA351 | Soluble, ND | |
| 338GTEVVGSAEAGVDA351 | Soluble, ND | |
a Insoluble in aqueous solution, DMSO, and HFIP.
b Soluble, soluble in aqueous solution.
c ND, amyloid was not detected.