FIGURE 3.

Antitumor effects of CH12 and C225 on Huh7-EGFRvIII or SMMC-7721 xenografts in established models. Huh7-EGFRvIII or SMMC-7721 cells (3 × 10⁶) were subcutaneously injected into 4-to-6-week-old nude mice when tumors had reached a mean tumor volume of 200 mm³. The mice were then randomly allocated into three groups (n = 6) and treated with (i) vehicle (sterile PBS), (ii) 25 mg/kg C225 in sterile PBS, or (iii) 25 mg/kg CH12 in sterile PBS. Injections were administered intraperitoneally three times per week for 2 weeks. *, CH12 group versus control group (p < 0.05); **, CH12 group versus C225 group (p < 0.05). In A and C, the data are expressed as mean tumor volumes. In B and D, the data are expressed as the percentage inhibition of tumor growth. (Bars, S.E.)