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Mechanisms of antitumor activity following treatment with CH12 and C225. Established SMMC-7721 (A) and Huh7-EGFRvIII (B) xenografts treated with PBS, CH12, or C225 as single agents were excised and prepared by homogenization in cell lysis buffer. Tumor lysates (30 μg) were then subjected to SDS-polyacrylamide gels and immunoblotted for total EGFR, phospho-EGFR (Tyr1068), total Akt, phospho-Akt, total ERK, phospho-ERK, cyclin D1, Bcl-xL, Bcl-2, and p27 as indicated.
