Table 2.
Average Change in CD4+ Count by Time Since HAART Initiation: All Participants and Viral Suppressors in U.S. Military HIV Natural History Study
| CD4+ strata | Estimated CD4+ count change and 95% CI (cells/mm3) by time segment (Years from HAART initiation) | ||
|---|---|---|---|
| at HAART start | 0-0.5 yrs | 0.5-4.0 yrs | >4.0 yrs |
| (change/half-year) | (change/year) | (change/year) | |
| ≤200 cells/mm3 | |||
| All participants | 109 (93, 126) | 36 (30, 43) | 8.6 (3.3, 14.0) |
| Viral suppressors | 147 (123, 172) | 66 (56, 75) | 13.6 (6.0, 21.2) |
| 201-349 cells/mm3 | |||
| All participants | 149 (135, 162) | 34 (28, 39) | 3.5 (-1.3, 8.4) |
| Viral suppressors | 171 (155, 188) | 54 (48, 60) | 14.4 (8.5, 20.4) |
| 350-499 cells/mm3 | |||
| All participants | 151 (136, 166) | 22 (16, 28) | 1.5 (-3.4, 6.4) |
| Viral suppressors | 177 (159, 195) | 51 (44, 57) | 12.0 (6.1, 17.8) |
| ≥500 cells/mm3 | |||
| All participants | 93 (75, 110) | 24 (17, 30) | -8.1 (-13.9, -2.4) |
| Viral suppressors | 119 (98, 139) | 56 (48, 63) | 16.2 (9.8, 22.6) |
* Significant (P < 0.05) differences in first-phase slopes: (1) All participants: ≤200 vs. 201-349; <200 vs. 350-499; 201-349 vs. ≥500; 350-499 vs. ≥500; (2) VL suppressors: 201-349 vs. ≥500; 350-499 vs. ≥500;
** Significant (P < 0.05) differences in second-phase slopes: (1) All participants: ≤200 vs. 350-499; (2) VL suppressors: None;
*** Significant (P < 0.05) differences in third-phase slopes: (1) All participants: ≤200 vs. ≥500; 201-349 vs. ≥500; 2) VL suppressors: None
(All P-values calculated with multiple comparisons adjustment)
HAART = Highly active antiretroviral therapy; CI = Confidence Interval