Table 3.
Adjusted Covariate Estimates * for CD4+ Cell Response Post-HAART for All Participants, U.S. Military HIV Natural History Study
| Covariate | Estimate (95% CI) | P-value |
|---|---|---|
| Age at HAART start | ||
| Effect of 10 years older if < 40 years old | 4.3 (-9.3, 17.9) | 0.54 |
| Effect of 10 years older if > 40 years old | - 7.7 (-23.3, 7.9) | 0.34 |
| Female (vs. Male) | 23.0 (-8.8, 54.8) | 0.16 |
| Race | ||
| Caucasian | Reference | |
| African American | -7.4 (-20.5, 5.7) | 0.27 |
| Hispanic | -35.0 (-57.8, -12.2) | 0.003 |
| Other | -0.7 (-35.4, 33.9) | 0.97 |
| Clinical AIDS event prior to HAART start | -23.3 (-46.1, -0.5) | 0.045 |
| Pre -HAART nadir CD4+ count (cells/mm3) | ||
| ≤ 200 | Reference | |
| 201-349 | 57.2 (31.4, 83.0) | <.001 |
| 350-499 | 160.8 (129.2, 192.5) | <.001 |
| ≥ 500 | 236.5 (196.4, 276.6) | <.001 |
| Baseline VL at HAART start (copies/ml) ** | ||
| < 1000 | 57.2 (32.5, 81.8) | <.001 |
| 1000-9999 | 40.2 (19.5, 60.8) | <.001 |
| 10,000-99,999 | 14.4 (-2.5, 31.3) | 0.10 |
| ≥ 100,000 | Reference | |
| Years from SC to HAART initiation | ||
| ≤ 1.5 | Reference | |
| > 1.5 to 4.0 | -28.3 (-47.8, -8.8) | 0.005 |
| > 4.0 to 8.5 | -44.1 (-65.3, -23.0) | <.001 |
| > 8.5 | -50.6 (-73.4, -27.9) | <.001 |
| Year of HAART initiation | ||
| 1995-1999 | -12.8 (-36.6, 10.9) | 0.29 |
| 2000-2003 | -34.4 (-60.3, -8.4) | 0.01 |
| 2004-2009 | Reference | |
| Any ART prior to HAART start | -16.4 (-34.4, 1.6) | 0.07 |
* Aside from baseline CD4+ count and time interval after HAART start
** Analysis adjusted for those for whom VL was missing/unknown.
HAART = Highly active antiretroviral therapy; ART = Antiretroviral therapy;
VL = HIV Viral load; SC = Seroconversion;