Table 4.
Adjusted Covariate Estimates* for CD4+ Cell Response Post-HAART for Viral Suppressors, U.S. Military HIV Natural History Study
| Covariate | Estimate (95% CI) | P-value |
|---|---|---|
| Age at HAART start | ||
| Effect of 10 years older if < 40 years old | 6.3 (-9.6, 22.2) | 0.44 |
| Effect of 10 years older if > 40 years old | - 5.1 (-23.9, 13.7) | 0.59 |
| Female (vs. Male) | 57.2 (14.6, 99.8) | 0.009 |
| Race | ||
| Caucasian | Reference | |
| African American | 9.2 (-7.3, 25.7) | 0.27 |
| Hispanic | -10.8 (-38.6, 17.1) | 0.45 |
| Other | 0.4 (-40.6, 41.4) | 0.98 |
| Clinical AIDS event prior to HAART start | -32.7 (-66.4, 1.0) | 0.057 |
| Pre -HAART nadir CD4 count (cells/mm3) | ||
| ≤ 200 | Reference | |
| 201-349 | 55.3 (20.7, 89.9) | 0.002 |
| 350-499 | 135.4 (94.6, 176.2) | <.001 |
| ≥ 500 | 195.1 (144.3, 245.8) | <.001 |
| Baseline VL at HAART start (copies/ml) ** | ||
| < 1000 | 8.5 (-21.6, 38.6) | 0.58 |
| 1000-9999 | -17.8 (-43.5, 7.9) | 0.18 |
| 10,000-99,999 | 1.3 (-19.5, 22.2) | 0.90 |
| ≥ 100,000 | Reference | |
| Years from SC to HAART initiation | ||
| ≤ 1.5 | Reference | |
| > 1.5 to 4.0 | -18.0 (-38.6, 2.6) | 0.09 |
| > 4.0 to 8.5 | -27.7 (-52.0, -3.3) | 0.03 |
| ≥ 8.5 | -33.4 (-61.0, -5.8) | 0.02 |
| Year of HAART initiation | ||
| 1995-1999 | 0.0 (-22.4, 22.4) | 0.99 |
| 2000-2003 | 5.9 (-18.1, 29.9) | 0.63 |
| 2004-2009 | Reference | |
| Any ART prior to HAART start | 11.5 (-11.1, 34.0) | 0.32 |
* Aside from baseline CD4+ count and time interval after HAART start
** Analysis adjusted for those for whom VL was missing/unknown.
HAART = Highly active antiretroviral therapy; ART = Antiretroviral therapy;
VL = HIV Viral load; SC = Seroconversion;