Table 3.
Multiple regression analysis showing association between SNPs in KCNQ1 and obesity and diabetes-related metabolic traits among non-diabetic controls
| Punjabi Cohort (n = 1,048) | rs231362 | rs2237892 | rs2237895 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Trait Mean | β (95%CI) | p adjustedΨ | β (95%CI) | p adjusted | β (95%CI) | p adjusted | ||||
| BMI (kg/m2) | 26.26 (25.94 - 26.58) | 0.01 (-0.59 - 0.71) | 0.860 | -0.05 (-3.03 - 0.46) | 0.150 | 0.04 (-0.23 - 1.13) | 0.192 | |||
| WHR | 0.94 (0.93 - 0.94) | -0.02 (-0.04 - -0.01) | 0.010 | 0.00 (-0.03 - 0.03) | 0.992 | -0.01 (-0.02 - 0.00) | 0.149 | |||
| FBG (mg/dL) | 95.18 (94.30 - 96.05) | -0.04 (-0.02 - 0.01) | 0.220 | -0.06 (-0.08 - 0.01) | 0.088 | -0.01 (-0.03 - 0.01) | 0.310 | |||
| INSULIN (IU/mL) | 7.35 (6.82 - 7.92) | 0.06 (-0.03 - 0.28) | 0.107 | 0.03 (-0.25 - 0.52) | 0.496 | -0.06 (-0.21 - 0.18) | 0.870 | |||
| HOMA-IR | 1.66 (1.54 - 1.80) | -0.04 (-0.46 - 0.15) | 0.309 | 0.02 (-0.30 - 0.49) | 0.634 | -0.11 (-0.32 - 0.93) | 0.282 | |||
| HOMA-B | 85.09 (77.74 - 93.14) | 0.05 (-0.06 - 0.27) | 0.223 | 0.07 (-0.08 - 0.81) | 0.106 | -0.07 (-0.43 - 0.03) | 0.091 | |||
| US Cohort (n = 569) | rs231362 | rs2237892 | rs2237895 | |||||||
| Trait Mean | β (95%CI) | p adjustedΨ | β (95%CI) | p adjusted | β (95%CI) | p adjusted | ||||
| BMI (kg/m2) | 26.19 (25.83 - 26.55) | 0.07 (-.030 - 2.43) | 0.124 | 0.09 (0.11 - 2.90) | 0.034 | 0.07 (-0.08 - 1.34) | 0.082 | |||
| WHR | 0.88 (0.87 - 0.89) | -0.02 (-0.04 - 0.00) | 0.197 | -0.04 (-0.26 - 0.10) | 0.395 | -0.04 (-0.05 - 0.01) | 0.289 | |||
| FBG (mg/dL) | 95.95 (95.05 - 96.85) | -0.01 (-0.03 - 0.00) | 0.086 | 0.04 (-0.02 - 0.06) | 0.373 | 0.03 (-0.02 - 0.03) | 0.536 | |||
| INSULIN (IU/mL) | 6.72 (6.37 - 7.09) | 0.04 (-0.05 - 0.12) | 0.393 | 0.01 (-0.99 - 1.19) | 0.862 | -0.09 (-0.15 - -0.05) | 0.037 | |||
| HOMA-IR | 1.57 (1.49 - 1.66) | 0.02 (-0.17 - 0.25) | 0.704 | 0.02 (-0.20 - 0.34) | 0.622 | -0.11 (-0.30 - -0.03) | 0.015 | |||
| HOMA-B | 79.71 (74.87 - 84.86) | 0.09 (-0.01 - 0.25) | 0.062 | -0.03 (-0.43 - 0.20) | 0.490 | -0.13 (-0.37 - -0.06) | 0.008 | |||
| Meta-analysis (n = 1,617) | rs231362 | rs2237892 | rs2237895 | |||||||
| Trait Mean | P(F)1 | P(R)2 | P(H)3 | P(F) | P(R) | P(H) | P(F) | P(R) | P(H) | |
| BMI (kg/m2) | 26.23 (25.99 - 26.48) | 0.856 | 0.849 | 0.051 | 0.640 | 0.990 | 0.010 | 0.463 | 0.463 | 0.670 |
| WHR | 0.91 (0.91 - 0.92) | 0.840 | 0.840 | 0.445 | 0.396 | 0.396 | 0.932 | 0.118 | 0.118 | 0.399 |
| FBG (mg/dL) | 95.48 (94.84 - 96.12) | 0.020 | 0.020 | 0.551 | 0.555 | 0.553 | 0.284 | 0.596 | 0.725 | 0.133 |
| INSULIN (IU/mL) | 7.09 (6.75 - 7.46) | 0.467 | 0.653 | 0.032 | 0.012 | 0.488 | 0.003 | 0.248 | 0.248 | 0.539 |
| HOMA-IR | 1.62 (1.54 - 1.71) | 0.689 | 0.689 | 0.738 | 0.078 | 0.630 | 0.001 | 0.616 | 0.616 | 0.680 |
| HOMA-B | 82.71 (78.06 - 87.63) | 0.062 | 0.062 | 0.912 | 0.475 | 0.766 | 0.293 | 0.009 | 0.009 | 0.532 |
| ΨP values were adjusted for age, gender and BMI in the Punjabi cohort; age, gender, BMI and place of birth in US cohorts; Bonferroni p = 0.008; 1p-value for fixed effect; 2p-value for random effect; 3 p-value for heterogeneity; measures on serum insulin, HOMA-IR, and HOMA-B were available in 657 of 1,048 control individuals in the Punjabi cohort. | ||||||||||