Table 2.
Significant regression values between gene or protein expression and scrapie-related lesions, as obtained by stepwise regression analysis
| Prion | Spongiosis | Vacuolation | GFAP | LGS | Caspase3 | |
|---|---|---|---|---|---|---|
| Medulla oblongata | ||||||
| HSP27 | 0.399 (0.003)1 |
-0.381 (0.016) |
ns2 | -0.443 (0.043) |
ns | ns |
| HSP72 | ns | ns | ns | ns | ns | ns |
| HSP73 | ns | ns | ns | ns | ns | ns |
| HSP90 | ns | ns | ns | ns | ns | ns |
| Hsp70p | ns | ns | ns | ns | ns | |
| Hsp90p | ns | ns | ns | ns | ns | ns |
| Cerebellum | ||||||
| HSP27 | -0.178 (0.032) |
ns | ns | 0.294 (0.0430) |
ns | ns |
| HSP72 | ns | ns | ns | ns | ns | ns |
| HSP73 | -0.719 (0.015) |
0.317 (0.023) |
ns | 0.783 (0.034) |
0.555 (0.018) |
ns |
| HSP90 | -0.465 (0.008) |
0.182 (0.039) |
ns | 0.712 (0.01) |
ns | ns |
| Hsp70p | ns | -0.014 (0.010) |
ns | ns | 0.022 (0.02) |
0.026 (0.010) |
| Hsp90p | ns | ns | ns | ns | ns | ns |
| Prefrontal cortex | ||||||
| HSP27 | -0.228 (0.004) |
ns | ns | 0.267 (0.025) |
-0.129 (0.038) |
ns |
| HSP72 | -0.347 (0.003) |
ns | ns | 0.277 (0.034) |
ns | ns |
| HSP73 | -0.271 (0.036) |
ns | ns | 0.381 (0.03) |
ns | ns |
| HSP90 | ns | ns | ns | ns | ns | ns |
| Hsp70p | ns | ns | -0.049 (0.015) |
0.045 (0.013) |
-0.023 (0.018) |
ns |
| Hsp90p | ns | ns | -0.080 (0.002) |
0.046 (0.015) |
-0.024 (0.020) |
ns |
| Diencephalon | ||||||
| HSP27 | ns | ns | ns | ns | ns | ns |
| HSP72 | ns | ns | ns | ns | ns | ns |
| HSP73 | ns | ns | ns | ns | ns | ns |
| HSP90 | ns | ns | ns | ns | ns | ns |
| Hsp70p | ns | -0.805 (0.001) |
ns | 0.778 (0.002) |
ns | ns |
| Hsp90p | ns | ns | ns | ns | ns | ns |
1Significant p-values (p < 0.05) are shown in brackets.
2 ns: regression values not statistically significant.