Table 2.
GSEA tests for GO classes enriched following chronic treatment
| GO term | GO definition | Size | ES | NES | NOM p-value |
|---|---|---|---|---|---|
| UP-regulated in treatment: | |||||
| GO:0006605 | Protein targeting | 85 | 0.387 | 1.416 | 0.054 |
| GO:0016485 | Protein processing | 32 | 0.413 | 1.267 | 0.086 |
| GO:0006897 | Endocytosis | 162 | 0.253 | 1.091 | 0.278 |
| GO:0000226 | Microtubule cytoskeleton organization and biogenesis | 28 | 0.376 | 1.004 | 0.484 |
| GO:0007409 | Axonogenesis | 29 | 0.362 | 0.992 | 0.614 |
| GO:0045893 | Positive regulation of transcription, DNA dependent | 270 | 0.200 | 0.898 | 0.502 |
| GO:0006887 | Exocytosis | 15 | 0.402 | 0.856 | 0.763 |
| GO:0006289 | Nucleotide-excision repair | 14 | 0.287 | 0.842 | 0.806 |
| GO:0007269 | Neurotransmitter secretion | 10 | 0.302 | 0.702 | 0.786 |
| DOWN-regulated in treatment: | |||||
| GO:0006917 | Induction of apoptosis | 208 | -0.286 | -1.093 | 0.396 |
| GO:0009615 | Response to virus | 21 | -0.301 | -1.198 | 0.130 |
| GO:0001756 | Somitogenesis | 17 | -0.356 | -1.020 | 0.502 |
Results for each GO-BP class identified by Klaper et al. [12,13], tested for enrichment by GSEA following chronic methylmercury treatment. Size refers to the number of genes in the set; ES and NES are the enrichment scores and normalized enrichment scores (respectively) for the set; NOM p-value is the nominal p-value for the NES.