Table 4.
GSEA tests for enrichment of HCC- and hepatitis-associated gene sets
| Gene Set Name | Size | ES | NES | NOM p-value |
|---|---|---|---|---|
| Up-regulated in acute liver treatment | ||||
| KUROKAWA_5FU_IFN_SENSITIVE_VS_RESISTANT_DN | 25 | 0.585 | 1.642 | 0.025 |
| WONG_IFNA_HCC_RESISTANT_VS_SENSITIVE_UP | 10 | 0.507 | 1.407 | 0.046 |
| Down-regulated in acute liver treatment | ||||
| HBX_HEP_UP | 12 | -0.540 | -1.460 | 0.038 |
| Up-regulated in chronic liver treatment | ||||
| HCC_SURVIVAL_GOOD_VS_POOR_DN | 112 | 0.452 | 1.549 | 0.000 |
| Down-regulated in chronic liver treatment | ||||
| None | ||||
Results for gene sets representing Hepatocellular carcinoma (HCC) and hepatitis, tested for enrichment by GSEA following methylmercury treatment. Here, we test whether liver-associated sets are enriched following methylmercury exposure. Size refers to the number of genes in the set; ES and NES are the enrichment scores and normalized enrichment scores (respectively) for the set; NOM p-value is the nominal p-value for the NES. Descriptions of each set (and lists of constituent genes) can be found by searching for set names at the MSigDB [8].