Figure 3.

The effect of BM-21 and thalassiolin B on nociception caused by formalin injection into the hind paw. A) No significant effect of BM-21 or amiloride was observed during the 1st-phase nociception, although indomethacin and thalassiolin B produced a significant reduction in the number of lickings. B) In the 2nd-phase, except for the lowest dose of the BM-21 (4 mg kg^-1), all the drugs used produced a significant reduction in the number of lickings. The magnitude of the thalassiolin B action was similar to that of amiloride and apparently larger than that produced by 15 mg kg^-1 indomethacin, but the difference was not significant (P = 0.302).