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ASIC-current type and effect of BM-21 on the ASIC currents. A) Typical pH-gated currents recorded in DRG cells (pH 6.1, 5 s). B) The use of 10 mg mL-1 BM-21 reduced the peak amplitude of the pH-gated current in a reversible form. C) The dose-response relationship of the BM-21 inhibitory effect on the ASIC currents in the DRG neurons was constructed pulling together cells with a desensitizing τ < 400 ms. The IC50 was 0.72 ± 0.16 mg mL-1.
