Table 8.
Evidence table of studies that examined changes in circulating ghrelin levels following H pylori eradication
| Reference & Country | Study Team | Design | Healthy | Gender | Age category | HP assess | Ghrelin assay Kit | Sample storage | Sample type | Weight | Sample size | Circulating Ghrelin levels after cure | Follow-up (wks) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nwokolo et al, 2003; UK [2] | A | Cohort | Healthy | Both | Adults | Serology and UBT | Commercial RIA | -20 | Plasma | Various | 10 | Increased | 6 |
| Jang et al, 2008; Korea [16] | B | Cohort | Sick | Both | Adults | RUT plus histology & confirmed by UBT | Commercial RIA | -70 | Plasma | Normal | 16 | Increased | Not stated |
| Osawa et al, 2006; Japan [46] | C | Cohort | Healthy | Men | Adults | Bacterial culture & histology | In-house RIA | Not stated | Plasma | Normal | 134 | Decreased | 12 |
| Czesnikiewicz-Guzik et al, 2007; Poland [13] | D | Cohort | Sick | Women | Adults | UBT; culture of saliva & supragingival dental plaques + serology | Commercial RIA | -80 | Plasma | Not stated | 49 | Increased | 4 |
| Lee et al, 2010; Korea [23] | B | RCT | Healthy | Both | Adults | RUT, histology (Giemsa stain) | ELISA | -70 | Plasma | Normal | 9 | No difference | 5 |
| Choe et al, 2007, Korea [6] | E | Cohort | Sick | Both | Adults | histology & PCR | Commercial ELISA | -70 | Plasma | Normal | 8 | No difference | 4 |
| Pacifico et al, 2008; Italy [26] | F | Cohort | Both | Both | Children | Culture of gastric specimen or histology + RUT | RIA | -70 | Serum | Normal | 22 | Decreased | 52 |
| Nweneka, et al, unpublished; Gambia | G | Cohort | Sick | Both | Children | UBT | Commercial RIA | -70 | Serum | Low | 3 | Decreased | 4 |
| Isomoto et al, 2005; Japan [36] | C | Cohort | Sick | Both | Adults | RUT, histology (Giemsa stain) | In-house RIA | -80 | Plasma | Normal | 43 | No difference | 4 |
| Isomoto et al, 2005; Japan[35] | C | Cohort | Sick | Both | Adults | RUT, histology (Giemsa stain) | In-house RIA | -80 | Plasma | Normal | 10 | No difference | 4 |
| Kawashima et al, 2009; Japan [38] | H | Cohort | Both | Both | Adults | Serology | Commercial EIA | -80 | Plasma | Normal | 49 | Increased | 23 |
| Cindoruk et al, 2007; Turkey [11] | I | Cohort | Sick | Both | Adults | Either histology or UBT | RIA | -80 | Plasma | Normal | 23 | No difference | 12 |
| Isomoto et al, 2004; Japan [34] | C | Cohort | Sick | Both | Adults | Serology | Commercial RIA | -80 | Plasma | Normal | 9 | No difference | 4 |