Table 4.
The selected published series on acute toxicity rate for postoperative external beam radiation therapy/intensity-modulated radiation therapy/helical tomotherapy for locally advanced head and neck cancer and/or oral cavity cancer patients
| Institute | Treatment (percentage of using chemotherapy) | Fistula formation/or skin dehiscence | *≥ Grade 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| dermatitis | mucosistis | Body weight loss | ^Xerostomia (acute) | Anemia | Leukopenia | Thrombocytopenia | |||
| RTOG 9501[4] | OP+RT+C/T | - | 8% | 30% | - | 2% | 38% (all of hematologic effects) | ||
| EORTC 22931[5] | OP+RT+C/T | - | - | 41% | - | 14% | - | 16% | - |
| RTOG 0024[14] | OP+RT+C/T | 11% | 29% | 60% | - | - | 12% (all of hematologic effects) | ||
| Yu et al.[23] | OP+RT | 8-29% | - | - | - | - | - | - | - |
| Jeremic et al.[24] | RT+C/T | - | - | - | 29% | - | - | - | - |
| Capuano et al.[25] | RT+C/T | - | - | - | 17% | - | - | - | - |
| Gomez et al.[19] | OP+IMRT +C/T (29%) | - | 3% | 23% | - | 0% | - | - | - |
| Chen WC et al. Taiwan [17] | OP+IMRT +C/T (9%) | - | 0 | 14% | - | - | - | - | - |
| FEMH, Taiwan | OP+HT +C/T (84%) | 11% | 5% | 42% | `0% | `0% | 0% | 5% | 0% |
^Toxicity of xelostomia (Acute): Acute toxicities is defined as occurring < 90 days after beginning RT.
*The grade of toxicity is according to the Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0).
Abbreviations:
OP = operation; RT = External beam radiation therapy; IMRT = intensity-modulated radiation therapy; HT = helical tomotherapy; C/T chemotherapy; FEMH = Far Eastern Memorial Hospital.