Table 4.
Prevalence of pfdhfr- pfdhps haplotypes in P. falciparum isolates from southern Pakistan.
|
Pfdhfr N51I, C59R, S108N, I164L Pfdhps S436A, A437G, K540E* |
No. of isolates | ||||
|---|---|---|---|---|---|
| No. of mutations |
Karachi (n = 158) |
Sindh (n = 47) |
Baluchistan (n = 9) |
Total (n = 214) |
|
| NCSI-SAK | 0 | - | 1 (0.02) | - | 1 (0.005) |
| NRNI-SGK | 3 | 80 (0.51) | 9 (0.19) | 5 (0.55) | 94 (0.44) |
| NRNI-SAK | 2 | 55 (0.35) | 33 (0.70) | 4 (0.45) | 92 (0.43) |
| IRNI-SGK | 4 | 1 (0.006) | - | - | 1 (0.005) |
| IRNI-SGE | 5 | 1 (0.006) | - | - | 1 (0.005) |
| IRNI-SAK | 3 | 4 (0.03) | 1 (0.02) | - | 5 (0.02) |
| ICNI-SAK | 2 | 5 (0.03) | - | - | 5 (0.02) |
| ICNI-SGK | 3 | 3 (0.02) | 1 (0.02) | - | 4 (0.02) |
| ICNI-SGE | 4 | 2 (0.01) | - | - | 2 (0.01) |
| NCNI-SAK | 1 | 3 (0.02) | - | - | 3 (0.01) |
| NCNI-SGK | 2 | 2 (0.01) | 2 (0.04) | - | 4 (0.02) |
| NCSI-AAK | 1 | 1 (0.006) | - | - | 1(0.005) |
| NCSI-SGK | 1 | 1 (0.006) | - | - | 1(0.005) |
pfdhfr-pfdhps haplotypes proportions are shown in brackets.
* Resistance associated alleles are indicated in bold.