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XOMA 052 cross-reacts with four species orthologs of IL-1β. Kinetic titration analysis of XOMA 052 binding to IL-1β from human (A), rhesus (B), rat (C) and mouse (D). Five concentrations of recombinant human, rhesus, rat and mouse IL-1β were injected in serial over XOMA 052 immobilized on a Biacore 2000 biosensor surface by aldehyde coupling. KD was determined by fitting data to a 1:1 Langmuir model using kinetic titration analysis with BIAevaluation software.
