Figure 6.

XOMA 052 inhibits IL-6 expression in IL-1β treated mice. Mice (n = 8 per treatment group) were injected with XMA005 parent, XOMA 052 or IgG control and treated 24 h later with 1 µg/kg of recombinant human IL-1β as described in Materials and Methods. Two hours later mice were sacrificed and neutralization activity of the antibodies was calculated by measuring the levels of IL-6 in the mouse serum. Percent neutralization was calculated using the mean of the IgG control treatment group as 100%. Both antibodies inhibited IL-6 stimulation in a dose-dependent manner with comparable potency. Values are mean percent neutralization, and error bars show standard error of the mean. The difference between XMA005 and XOMA 052 is not significant as measured by unpaired two-tailed t-test (p = 0.17, 0.41 and 0.36 for 0.15, 0.05 and 0.015 mg/kg doses, respectively).