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. 2011 Jan 1;3(1):67–75. doi: 10.4161/mabs.3.1.14021

Table 4A.

Single dose pharmacokinetic parameters of CMAB009: non-compartmental analysis

Parameters (units) CMAB009 dose (mg/m2)
100 250 400
Ke (h−1) 0.015 ± 0.002 0.009 ± 0.001 0.009 ± 0.002
Tl/2ke (h) 47.47 ± 6.61 78.42 ± 6.23 83.58 ± 15.86
AUC0-t (µg.h/mL) 2939.01 ± 569.47 15525.30 ± 4797.02 26615.95 ± 4827.53
AUCt-∞ (µg.h/mL) 16.59 ± 11.46 39.51 ± 23.46 1561.42 ± 1294.44
AUC0-∞ (µg.h/mL) 2955.60 ± 571.57 15564.81 ± 4812.12 28177.37 ± 5647.10
AUC0-t % 99.43 ± 0.35 99.76 ± 0.10 94.80 ± 3.77
MRT (h) 66.66 ± 3.98 124.43 ± 20.90 121.79 ± 22.24
C//F (mL/h.m2) 34.81 ± 7.55 17.63 ± 6.18 14.68 ± 2.93
VSS (mL/m2) 2300.28 ± 348.73 2116.88 ± 526.31 1745.34 ± 258.95