Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
DVL is a mediator of classical GPCRs for β-catenin stabilization. Wnt-induced β-catenin stabilization is mediated via frizzled receptors that are considered as atypical GPCRs. Classical GPCRs such as parathyroid hormone receptor (PTH1R) and proteinase-activated—receptor1 (PAR1) lead to β-catenin increased levels by recruiting DVL. Thus, DVL serves as a junction mediator routing the classical GPCR for β-catenin stabilization.
