Table 3.
Effects of once daily 30 mg/kg treatment with the dopamine 1/5 receptor agonist SKF 81297 on atrophying skeletal muscle mass in wild-type (+/+ D1R) and dopamine 1 receptor homozygous knockout (-/- D1R) mice
| Parameter | Uncasted Vehicle +/+ D1R |
Casted Vehicle +/+ D1R |
Casted SKF 81297 +/+ D1R |
Uncasted Vehicle -/- D1R |
Casted Vehicle -/- D1R |
Casted SKF 81297 -/- D1R |
|---|---|---|---|---|---|---|
| # mice | 12 | 11 | 10 | 11 | 11 | 11 |
| Initial body mass (grams) |
24.6 (1.0) |
24.4 (0.9) |
24.1 (1.1) |
22.1 (1.1) |
22.3 (1.1) |
21.6 (0.8) |
| Final body mass (grams) |
24.9 (1.0) |
24.2 (0.8) |
25.8#* (1.2) |
23.6 (1.1) |
22.6# (1.1) |
23.0# (0.9) |
| EDL mass (milligrams) |
9.8 (0.4) |
7.4# (0.4) |
8.4#* (0.5) |
9.6 (0.4) |
7.5# (0.5) |
7.4# (0.4) |
| EDL Po (milliNewtons) |
402.8 (16.0) |
315.0# (15.6) |
359.5#* (22.7) |
371.0 (11.0) |
317.8# (22.1) |
307.6# (16.3) |
| Soleus mass (milligrams) |
7.6 (0.3) |
5.0# (0.3) |
5.6#* (0.4) |
6.9 (0.3) |
4.6# (0.3) |
4.8# (0.3) |
| Soleus Po (milliNewtons) |
209.3 (6.1) |
149.0# (6.8) |
164.2# (12.0) |
196.2 (11.3) |
119.7# (7.1) |
121.4# (7.0) |
All data given as mean + (SEM). * - statistically significant (p < 0.05) versus casted vehicle; # - statistically significant (p < 0.05) versus uncasted vehicle.