Table 4.
Effects of daily 30 mg/kg dosing with the dopamine 1/5 receptor agonist SKF 81297 on atrophying skeletal muscle mass and force in wild-type (+/+ D5R) and dopamine 5 receptor homozygous knockout (-/- D5R) mice.
| Parameter | Uncasted Vehicle +/+ D5R |
Casted Vehicle +/+ D5R |
Casted SKF 81297 +/+ D5R |
Uncasted Vehicle -/- D5R |
Casted Vehicle -/- D5R |
Casted SKF 81297 -/- D5R |
|---|---|---|---|---|---|---|
| # mice | 12 | 12 | 12 | 12 | 12 | 12 |
| Initial body mass (grams) |
23.0 (0.5) |
22.7 (0.3) |
22.3 (0.6) |
22.3 (0.3) |
22.5 (0.4) |
21.8 (0.4) |
| Final body mass (grams) |
23.0 (0.4) |
21.6# (0.4) |
22.8* (0.7) |
23.1 (0.4) |
21.3# (0.5) |
22.4#* (0.4) |
| EDL mass (milligrams) |
8.8 (0.2) |
6.0# (0.2) |
6.6#* (0.3) |
8.8 (0.2) |
5.9# (0.2) |
6.2# (0.2) |
| EDL Po (milliNewtons) |
351.3 (10.8) |
237.3# (8.0) |
269.7#* (13.6) |
348.4 (10.5) |
233.1# (9.2) |
256.0# (12.1) |
| Soleus mass (milligrams) |
7.5 (0.2) |
4.5# (0.2) |
4.6# (0.2) |
7.4 (0.2) |
5.0# (0.2) |
4.9# (0.2) |
| Soleus Po (milliNewtons) |
202.2 (8.2) |
120.7# (8.1) |
130.0# (8.5) |
204.2 (7.6) |
132.8# (8.4) |
129.9# (7.1) |
All data given as mean + (SEM). * - statistically significant (p < 0.05) versus casted vehicle; # - statistically significant (p < 0.05) versus uncasted vehicle.