Table 1.
Steroid Concentrations among Non-Tested and Tested Same-aged rats with Maintaining or Declining Reproductive Status
|
Non-Tested Middle-Aged Control Rats |
Maintaining (n=3) |
Declining (n=3) |
|---|---|---|
| Corticosterone (μg/dl±SEM) | 0.8 ± 0.2 | 0.8 ± 0.3 |
| Medial Prefrontal Cortex | ||
| E2 (pg/g±SEM) | 3.9 ± 1.8 | 3.5 ± 1.0 |
| P4 (ng/g±SEM) | 3.5 ± 0.3 | 6.0 ± 1.7 |
| DHP (ng/g±SEM) | 2.2 ± 0.3 | 3.4 ± 0.7 |
| 3α,5α-THP (ng/g±SEM) | 5.4 ± 2.7 | 8.6 ± 1.4 |
| P4 Turnover (DHP+3α,5α-THP:P ratio) |
2.3 ± 1.0 | 2.2 ± 0.4 |
| Hippocampus | ||
| E2 (pg/g±SEM) | 4.7 ± 3.4 | 4.4 ± 4.0 |
| P4 (ng/g±SEM) | 7.1 ± 2.4 | 8.6 ± 2.3 |
| DHP (ng/g±SEM) | 3.9 ± 0.4 | 4.8 ± 0.8 |
| 3α,5α-THP (ng/g±SEM) | 12.5 ± 2.5 | 13.4 ± 5.3 |
| P4 Turnover (DHP+3α,5α-THP:P4 ratio) |
2.8 ± 0.9 | 2.1 ± 0.4 |
| Tested Middle-Aged Rats | Maintaining (n=14) |
Declining (n=12) |
|---|---|---|
| Corticosterone (μg/dl±SEM) | 1.4 ± 0.2 | 1.3 ± 0.3 |
| Medial Prefrontal Cortex | ||
| E2 (pg/g±SEM) | 4.1 ± 1.4 | 2.3 ± 0.9 |
| DHP (ng/g±SEM) | 1.2 ± 0.1 | 1.9 ± 0.6 |
| P4 Turnover (DHP+3α,5α-THP:P ratio) |
16.5 ± 6.1 | 7.9 ± 3.0 |
| Hippocampus | ||
| E2 (pg/g±SEM) | 6.2 ± 1.8 | 7.0 ± 2.2 |
| DHP (ng/g±SEM) | 1.9 ± 0.2 | 2.5 ± 0.8 |
| P4 Turnover (DHP+3α,5α-THP:P4 ratio) |
9.6 ± 3.7 | 8.0 ± 2.9 |
Depicts concentrations of corticosterone, estradiol (E2), progesterone (P4), dihydroprogesterone (DHP), 3α,5α-THP, and/or P4 turnover to its 5α-reduced metabolites (DHP and 3α,5α-THP) in medial prefrontal cortex and hippocampus among a subset of same-aged, 12-month-old rats that were non-tested controls or were tested in the behavioral battery described.