Monomer, dimer and tetramer populations of ApoE isoforms as a function of total concentration.
A-C) simulation of monomer, dimer and tetramer populations as a function of the total ApoE concentration for apoE4 (□), ApoE3 (○) and ApoE2 (✰) respectively. D, percent populations of monomers (■), dimers (●) and tetramers (▲) for ApoE4. The simulations have been performed using Kintek explorer (35) and the rate constants obtained from kinetics experiments for ApoE4, serine mutants of ApoE3 and ApoE2 as listed in Table 1.