A) Chronic treatment of cerebellar slice cultures with NASP (100 μM) from 1 to 14 DIV significantly increases GluRδ2+/Lc Purkinje cell survival (* ANOVA, F1,12 = 29.4 , p < 0.0005), but does not affect the survival of GluRδ2+/+ Purkinje cells. In addition, NASP treatment promotes dendritic differentiation in the mutant Purkinje cells (D) compared with untreated GluRδ2+/Lc Purkinje cells (C). The NASP treated GluRδ2+/Lc Purkinje cells appear similar to NASP treated wild type Purkinje cells (B). Scale bar 50 μM.