TABLE 2.
RELEASE KINETICS PARAMETERS FOR DESIGNED FORMULATIONS
| Parameters | IE1C0 | IE1C2 | IE1C3 | IE2C0 | IE2C3 | IE2C4 | IE4C0 |
|---|---|---|---|---|---|---|---|
| ra | 0.9973 | 0.9926 | 0.9814 | 0.9830 | 0.9780 | 0.9729 | 0.9754 |
| Kb | 0.0770 | 0.0941 | 0.0871 | 0.0658 | 0.0883 | 0.0905 | 0.0365 |
| nc | 0.72 | 0.85 | 0.87 | 0.66 | 1.38 | 1.32 | 0.54 |
| t10%d | 1.1 | 1.1 | 2.4 | 1.3 | 2.4 | 2.6 | 1.3 |
| t50%e | 7.5 | 6.9 | 7.9 | 13.5 | 7.6 | 7.9 | 15.0 |
| t90%f | 14.9 | 15.2 | 14.5 | 27.1 | 14.2 | 14.4 | 29.1 |
a
Correlation coefficient.
b
Release rate constant.
c
Diffusional exponent indicative of the release mechanism.
d
Time for 10% of the drug release (in h).
e
Time for 50% of the drug release (in h).
f
Time for 90% of the drug release (in h).