TABLE 2.
DIURETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF RUNGIA PECTINATA AND RUNGIA REPENS.
| Group | Treatment (n=6) | Volume of Urine (ml) | Concentration in mEq/l of Urine at 24 h | |||
|---|---|---|---|---|---|---|
| 5 h | 24 h | Sodium | Potassium | Chloride | ||
| I | Normal saline (25 ml/kg) | 3.58±0.16 | 6.21±0.11 | 89.98±1.41 | 61.16±0.87 | 90.88±1.34 |
| II | Frusemide (20 mg/kg) | 5.4±0.21* | 8.21±0.25* | 120.2±1.40* | 90.26±0.96* | 96.33±1.11* |
| III | R. repens (400 mg/kg) | 4.20±0.21 | 7.71±0.32* | 127.25±1.02* | 78.43±1.15* | 91.46±0.92 |
| IV | R. repens (800 mg/kg) | 4.83±0.13* | 7.9±0.29* | 128.08±1.28* | 79.58±2.81* | 90.26±1.46 |
| V | R. pectinata (400 mg/kg) | 3.78±0.12 | 6.76±0.21 | 90.68±1.17 | 70.53±1.15* | 97.48±1.21* |
| VI | R. pectinata (800 mg/kg) | 4.33±0.19* | 7.15±0.25* | 126.45±1.32* | 75.21±1.21* | 90.20±1.44* |
Each value is mean ±SEM (n = 6, that is two groups of three animals each);
*
Denotes significant difference when compared to control values at P <0.05, ANOVA followed by Dunnett's t-test.