. Author manuscript; available in PMC: 2011 Feb 14.

Published in final edited form as: Brain Struct Funct. 2010 Mar 7;214(2-3):145–160. doi: 10.1007/s00429-010-0242-4

Table 3.

Summary of data on PV and CR expression in neuronal subpopulations

Region	Tissue source	Marker	Outcome
CA1-2-SP	APP^SL mice	PV	No difference in the number of PV-ir neurons with age
	PS1he KI mice	PV	43.8% reduction in number of PV-ir neurons with age
	PS1ho KI mice	PV	49.4% reduction in number of PV-ir neurons with age
	APP^SL/PS1ho KI mice	PV	42.7% reduction in number of PV-ir neurons with age
DG-SG and hilus	PS1ho KI mice	CR	37.8% reduction in number of CR-ir neurons with age
	APP^SL/PS1ho KI mice	CR	51.6% reduction in number of CR-ir neurons with age; 49.3% reduction in density of CR-ir neurons with age
	Human AD brains	PV	PV-ir neurons distributed within or close to the stratum granulare; no change in density from AD cases compared to controls
	Human AD brains	CR	CR-ir neurons mainly distributed in the hilar region of the dentate gyrus; 63.2% reduction in the densities of CR-ir neurons from AD cases compared to controls

DG-SG dentate gyrus-stratum granulare and hilus, CA1-2 area CA1-2 (stratum pyramidale), PV parvalbumin, CR calretinin