TABLE 1.
Immunohistochemical Analyses of the Uterine Smooth Muscle Lesions and Their Associated Pulmonary Manifestations
| Histologic Diagnosis | p53* | Ki67 Index† | bcl-2* |
|---|---|---|---|
| Leiomyomas | 0/8 | 2.3 (0.9–8.8) | 8/8 |
| Leiomyosarcomas | 9/15 | 28.6 (14.4–62.0) | 12/12 |
| Benign metastasizing leiomyomas | 0/10 | 3.4 (0.7–8.1) | 5/6 |
*
p53 and bcl-2 scoring was defined as positive if at least 10% of the cells showed a clear-cut nuclear signal; in 4 of the benign metastasizing leiomyomas and 3 of the leiomyosarcomas, the bcl-2 test was not performed.
†
The Ki67 index was defined as the percentage of cells with a strong nuclear signal per 100 cells—at least 600 cells were counted per case.