Figure 1.

SDF1 reduces branching frequency. A, Phase microscopy of migrating interneurons exhibiting leading process branching (*), interstitial branching (**), and somal translocation (arrowheads) in control neurons. B (and supplemental Fig. 1, video 1), SDF1-treated interneurons show decreased branching frequency and faster somal translocation. C, D, Quantification of speed and branching of individual interneurons treated with SDF1 shows an increase in speed and a decrease in both leading process splitting and interstitial branching. Error bars are ± SEM (***p < 0.001, t test); 45 cells for each condition; three independent experiments. Scale bar, 50 μm.