. Author manuscript; available in PMC: 2012 Mar 1.

Published in final edited form as: Pharmacogenet Genomics. 2011 Mar;21(3):130–135. doi: 10.1097/FPC.0b013e3283436b86

Table 4.

Linear regression stepwise modeling association between mean weekly warfarin dose (square root transformed) as a dependent variable and genetic and nongenetic factors as independent variables

Predictor	Coefficient	Standard error	Partial R² (%)	P value
Intercept	8.06	0.32
VKORC1 3673 genotype	−0.63	0.13	10.33	< 0.0001
Age (decades)	−0.30	0.06	8.11	< 0.0001
CYP2C9	−0.41	0.14	5.17	0.0004
Pulmonary embolism	1.44	0.56	3.0	0.0059
APOE ε2	−0.60	0.22	2.53	0.01
Smoking status	0.58	0.26	1.88	0.025
Model R²			31.02	< 0.0001