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PRKAR1A and PDE11A silencing increase PKA-dependent transcription at baseline and after forskolin stimulation. PRKAR1A inactivation (gray bars), PDE11A inactivation (white striped bars) in HEK293 cells increases transcriptional activity of the reporter construct; coinactivation of PRKAR1A and PDE11A (gray striped bars) led to an additive effect, and similar results were found after forskolin stimulation. *, P < 0.05.
