Table 2.

Effects of tesamorelin on GH pulse parameters (deconvolution analysis) and insulin sensitivity

	Entire cohort (n = 13)			BMI >25 kg/m2 (n = 8)
	Baseline	2 wk	4 wk	Baseline	2 wk	4 wk
GH secretion
Mean overnight GH (μg/liter)	0.7 ± 0.2	1.2 ± 0.3a	0.8 ± 0.2	0.2 ± 0.1	0.6 ± 0.2	0.3 ± 0.1
Basal secretion (μg/liter · min)	0.003 ± 0.001	0.011 ± 0.002b	0.002 ± 0.001	0.001 ± 0.0003	0.011 ± 0.003b	0.001 ± 0.0002
GH half-life (min)	13.6 ± 0.8	14.9 ± 2.5	16.3 ± 1.3b	12.7 ± 0.8	12.8 ± 3.4	15.1 ± 1.4
GH peaks (n per 12 h)	10 ± 1	10 ± 1	8 ± 1	10 ± 1	10 ± 1	9 ± 1
GH AUC (μg/liter per 12 h)	531 ± 166	897 ± 211a	549 ± 170	172 ± 42	423 ± 136	180 ± 48
Mean log10 GH peak area (log10 μg/liter)	−0.17 ± 0.16	0.26 ± 0.11a	−0.19 ± 0.21	−0.53 ± 0.14	0.02 ± 0.08b	−0.65 ± 0.19
GH maximum (μg/liter)	4.2 ± 1.0	4.2 ± 1.1	4.2 ± 1.0	1.8 ± 0.5	2.7 ± 1.4	1.8 ± 0.6
GH nadir (μg/liter)	0.05 ± 0.02	0.28 ± 0.10b	0.05 ± 0.02	0.02 ± 0.002	0.13 ± 0.04b	0.02 ± 0.01
IGF-I (μg/liter)	148 ± 15	329 ± 28a	161 ± 13	138 ± 15	308 ± 34a	150 ± 14
Insulin sensitivity
Fasting glucose (mg/dl)	90 ± 2	90 ± 2	88 ± 2	92 ± 2	93 ± 2	91 ± 2
M (mg/kg · min)	7.2 ± 1.1	7.5 ± 1.2	7.9 ± 1.2	5.3 ± 0.8	5.7 ± 0.7	5.5 ± 1.0
M/I per LBM (mg/kg LBM per μU/ml insulin per min)	0.17 ± 0.03	0.19 ± 0.03	0.22 ± 0.05	0.13 ± 0.02	0.14 ± 0.04	0.13 ± 0.04
HOMA-IR	1.3 ± 0.3	2.0 ± 0.6	1.2 ± 0.4	1.7 ± 0.4	2.8 ± 0.8	1.7 ± 0.5

Values are mean ± sem. M is insulin-stimulated glucose uptake calculated between 100 and 120 min of the euglycemic hyperinsulinemic clamp procedure. M/I per LBM is insulin-stimulated glucose uptake indexed to fat-free mass and divided by serum insulin concentration. GH pulse parameters determined by the automated deconvolution algorithm AutoDecon. AUC, Area under the curve. 

^aP < 0.005 compared with baseline by paired t test. 

^bP < 0.05 compared with baseline by paired t test.