Table 1.

Allele frequency (minor allele) of sequence variations in PDE11A in PCa patients and control individuals

Sequence change	PCa patients (100 alleles)	Controls			PC patients vs. controls
		Endo-negative (384 alleles)	Coriell (190 alleles)	Total (574 alleles)	χ2	P
c.171Tdel FS41X	1 (0.01)	0 (0.00)	2 (0.01)	2 (0.003)	0.01	Ns
R202Ca	1 (0.01)	0 (0.00)	0 (0.00)	0 (0.00)	0.98	Ns
A349T	0 (0.00)	1 (0.002)	1 (0.005)	2 (0.003)	0.16	Ns
D609N	0 (0.00)	0 (0.00)	1 (0.005)	1 (0.002)	0.98	Ns
Y658Ca	1 (0.01)	0 (0.00)	0 (0.00)	0 (0.00)	0.98	Ns
Y727C	5 (0.05)	0 (0.00)	6 (0.03)	6 (0.01)	6.02	0.014
R804H	3 (0.03)	5 (0.01)	2 (0.01)	7 (0.012)	0.83	Ns
E840Ka	2 (0.02)	0 (0.00)	0 (0.00)	0 (0.00)	5.75	0.017
R867G	1 (0.01)	5 (0.01)	5 (0.03)	10 (0.017)	0.01	Ns
M878V	2 (0.02)	0 (0.00)	1 (0.005)	1 (0.002)	2.95	Ns
Total	16 (0.16)	11 (0.029)	18 (0.094)	29 (0.05)	14.67	<0.001

χ² is calculated after Yates correction for continuity (Yates correction was applied for all calculations having a number less than 10 in any cell of the contingency table). Ns, Nonsignificant. 

^aNewly identified in the PCa patients only variations.