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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Exp Neurol. 2010 Nov 5;228(1):41–52. doi: 10.1016/j.expneurol.2010.10.016

Figure 5. Neuronal expression of GFP following intranigral delivery of VSV or MV-pseudotyped lentivirus vectors.

Figure 5

The images show confocal micrographs of the substantia nigra from animals that received intranifral infusions of VSV (A-F) or MV (G-L) pseudotyped lentiviral vectors 21 days previously. Sections were labeled by indirect immunofluorescence in order to detect GFP (green; A, D, G, J) and tyrosine hydroxylase (red; B, E, H, K). Low magnification images (A-C, G-I; bar = 50 μm) illustrate the relative topographical distributions of transduced neurons and dopaminergic neurons. High magnification images (D-F, J-L bar = 20 μm) demonstrate examples of vector-transduced dopamine neurons, identified by co-expression of GFP and TH (arrowheads).